Angiogenesis modulates adipogenesis and obesity

J Clin Invest. 2007 Sep;117(9):2362-8. doi: 10.1172/JCI32239.


Substantial evidence shows that neoplastic and nonneoplastic tissue growth is dependent on angiogenesis. Neovascularization and adipogenesis are temporally and spatially coupled processes during prenatal life and they continue to reciprocally interact via paracrine signaling systems throughout adult life. Activated adipocytes produce multiple angiogenic factors including leptin, angiopoietins, HGF, GM-CSF, VEGF, FGF-2, and TGF-beta, which either alone or collectively stimulate neovascularization during fat mass expansion. Thus antiangiogenic agents provide a novel therapeutic option for prevention and treatment of human obesity and its related disorders.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipocytes / drug effects
  • Adipocytes / metabolism
  • Adipogenesis*
  • Angiogenesis Inducing Agents / pharmacology
  • Animals
  • Cell Communication
  • Endothelial Cells / metabolism
  • Humans
  • Neovascularization, Pathologic / metabolism
  • Neovascularization, Pathologic / pathology*
  • Obesity / metabolism
  • Obesity / pathology*
  • Obesity / therapy


  • Angiogenesis Inducing Agents