MicroRNAs: powerful new regulators of heart disease and provocative therapeutic targets

J Clin Invest. 2007 Sep;117(9):2369-76. doi: 10.1172/JCI33099.


MicroRNAs act as negative regulators of gene expression by inhibiting the translation or promoting the degradation of target mRNAs. Recent studies have revealed key roles of microRNAs as regulators of the growth, development, function, and stress responsiveness of the heart, providing glimpses of undiscovered regulatory mechanisms and potential therapeutic targets for the treatment of heart disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation
  • Genetic Therapy
  • Heart Diseases / genetics*
  • Heart Diseases / pathology
  • Heart Diseases / physiopathology
  • Heart Diseases / therapy*
  • Humans
  • MicroRNAs / genetics*
  • Myocardial Contraction
  • Phenotype


  • MicroRNAs