Expression profile of class I histone deacetylases in human cancer tissues

Oncol Rep. 2007 Oct;18(4):769-74.


Histone deacetylase (HDAC) activity is one of the widely used and well-established mechanisms for regulation of various genes in cancer. To identify which subtype of class I HDACs are overexpressed in cancers, we analyzed the expression of class I HDAC isotypes composed of HDAC1, 2, 3 and 8 in several cell lines and human cancer tissues, including cancer of the stomach, esophagus, colon, prostate, breast, ovary, lung, pancreas and thyroid. The results showed that >75% of human cancer tissues and their corresponding non-cancerous epithelium showed high expression of these class I HDACs. However, the immunoreactivity of HDAC8 in both prostatic cancer tissue and non-cancerous prostate glands was lower than that in other cancer tissues. Furthermore, 5-40% of cancer tissues overexpressed class I HDACs, when compared with normal epithelium. The results suggest the potential usefulness of HDAC inhibitors for the treatment of a wide variety of human cancers.

MeSH terms

  • Blotting, Western
  • Epithelial Cells / enzymology
  • Epithelial Cells / pathology
  • Gene Expression Regulation, Neoplastic
  • Histone Deacetylase 1
  • Histone Deacetylase 2
  • Histone Deacetylases / metabolism*
  • Humans
  • Immunoblotting
  • Neoplasms / enzymology*
  • Neoplasms / pathology
  • Repressor Proteins / metabolism
  • Tumor Cells, Cultured


  • Repressor Proteins
  • HDAC1 protein, human
  • HDAC8 protein, human
  • Histone Deacetylase 1
  • Histone Deacetylase 2
  • Histone Deacetylases
  • histone deacetylase 3