Functional significance of vascular endothelial growth factor receptors on gastrointestinal cancer cells

Cancer Metastasis Rev. 2007 Dec;26(3-4):433-41. doi: 10.1007/s10555-007-9070-2.


Vascular endothelial growth factor (VEGF) has been shown to be the major mediator of physiologic and pathologic angiogenesis. VEGF was initially thought to be an endothelial cell specific ligand, but recently, VEGF has been shown to mediate tumor cell function via activation of receptors on tumor cells themselves. Here, we review the expression patterns and binding profiles of the VEGF receptors and their ligands on gastrointestinal tumor cells. Furthermore, we describe the current knowledge in regards to the function of these receptors on tumor cells. Elucidating the function of VEGF receptors on tumor cells should help us to better understand the potential mechanisms of action of anti-VEGF therapies.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Colorectal Neoplasms / blood supply
  • Colorectal Neoplasms / drug therapy
  • Colorectal Neoplasms / pathology
  • Gastrointestinal Neoplasms / blood supply
  • Gastrointestinal Neoplasms / drug therapy*
  • Gastrointestinal Neoplasms / pathology
  • Humans
  • Neuropilin-1 / analysis
  • Neuropilin-1 / physiology
  • Pancreatic Neoplasms / blood supply
  • Pancreatic Neoplasms / drug therapy
  • Pancreatic Neoplasms / pathology
  • Receptors, Vascular Endothelial Growth Factor / analysis
  • Receptors, Vascular Endothelial Growth Factor / physiology*
  • Vascular Endothelial Growth Factor A / antagonists & inhibitors*
  • Vascular Endothelial Growth Factor A / physiology


  • Vascular Endothelial Growth Factor A
  • Neuropilin-1
  • Receptors, Vascular Endothelial Growth Factor