Novel properties of P450s in Streptomyces coelicolor

Drug Metab Rev. 2007;39(2-3):343-52. doi: 10.1080/03602530701498836.


In the process of investigating the function of the 18 P450s that make up the CYPome in the soil bacterium Streptomyces coelicolor, we have discovered new and novel biochemical features of some of these monooxygenases. This article which is dedicated to Ron Estabrook summarizes these discoveries with emphasis on their novelty. It is concluded from this work that there are many interesting features of P450 enzymes waiting to be discovered. Since there are more than 6500 P450 gene sequences known today, we can expect that many new biochemical aspects of P450s will be discovered as these individual monooxygenases are investigated.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Cytochrome P-450 Enzyme System / chemistry
  • Cytochrome P-450 Enzyme System / metabolism*
  • Heme / chemistry
  • Heme / metabolism
  • Models, Molecular
  • Streptomyces coelicolor / enzymology*


  • Heme
  • Cytochrome P-450 Enzyme System