Acute motor neuropathy with antibodies to GM1 ganglioside

J Neurol. 1991 Dec;238(8):447-51. doi: 10.1007/BF00314652.


We describe a 52-year-old man who had an acute-onset purely motor neuropathy fulfilling the diagnostic criteria for the Guillain-Barré syndrome, in whom virtually complete spontaneous recovery occurred by 1 year, and in whom high titres of polyclonal serum antibody to GM1, GD1b, asialo-GM1 and lacto-N-tetraose were detected. The titre of IgM antibody to GM1 fell during the course of the disease with a concomitant rise in the IgG titre. This case adds to the widening spectrum of disease associated with anti-GM1 antibodies and provides further evidence for a relationship between anti-GM1 antibodies and motor system disease.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Animals
  • Autoantibodies / blood
  • Autoantibodies / immunology*
  • Autoimmune Diseases / immunology*
  • G(M1) Ganglioside / immunology*
  • Humans
  • Immunoglobulin G / immunology
  • Immunoglobulin M / immunology
  • Male
  • Middle Aged
  • Polyradiculoneuropathy / immunology*
  • Ranvier's Nodes / immunology
  • Rats


  • Autoantibodies
  • Immunoglobulin G
  • Immunoglobulin M
  • G(M1) Ganglioside