Combination vaccine use and vaccination quality in a managed care population

Am J Manag Care. 2007 Sep;13(9):506-12.

Abstract

Objective: To evaluate the impact of a pentavalent combination vaccine on childhood immunization coverage rates and timeliness within a managed care organization.

Study design: Retrospective matched-cohort analysis of encounter data from administrative claims and a state immunization registry.

Methods: Children were stratified into 2 demographically matched cohorts (combination and reference), based on receipt of the DTaP/HepB/IPV combination vaccine. Children were followed until 24 months of age, and coverage rates and on-time rates were assessed. Outcomes were measured for the HEDIS Combination 2 vaccine series (4 doses of diphtheria/tetanus/pertussis, 3 doses of polio, 1 dose of measles/mumps/rubella, 3 doses of Haemophilus influenzae type b, 3 doses of hepatitis B, and 1 dose of varicella) and each vaccine series individually.

Results: Children in the combination cohort were significantly more likely to be fully vaccinated for the HEDIS Combination 2 series by 2 years of age and to be vaccinated within the recommended age ranges. In the combination cohort 86.9% (752/865) of patients were fully covered compared with only 74.1% (641/865) of the reference cohort (P <.001). In the combination cohort 45.2% (391/865) of patients received vaccinations on time versus 37.5% (324/865) of the reference cohort, P = .001.

Conclusions: Receipt of DTaP/HepB/IPV was associated with improved coverage and age-appropriate immunization in a managed care population.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chickenpox Vaccine / administration & dosage*
  • Child Health Services / organization & administration
  • Child Health Services / statistics & numerical data*
  • Child Welfare / statistics & numerical data
  • Child, Preschool
  • Cohort Studies
  • Female
  • Haemophilus Vaccines / administration & dosage*
  • Hepatitis B Vaccines / administration & dosage*
  • Humans
  • Immunization Programs / standards*
  • Immunization Programs / statistics & numerical data
  • Immunization Schedule*
  • Infant
  • Infant, Newborn
  • Male
  • Managed Care Programs / organization & administration
  • Managed Care Programs / standards*
  • Measles-Mumps-Rubella Vaccine / administration & dosage*
  • Quality Indicators, Health Care
  • Retrospective Studies
  • United States / epidemiology
  • Vaccination / statistics & numerical data*
  • Vaccines, Combined / administration & dosage*
  • Vaccines, Conjugate / administration & dosage

Substances

  • Chickenpox Vaccine
  • Haemophilus Vaccines
  • Hepatitis B Vaccines
  • Measles-Mumps-Rubella Vaccine
  • Vaccines, Combined
  • Vaccines, Conjugate
  • measles, mumps, rubella, varicella vaccine