Cortical circumferential profile of SPECT cerebral perfusion in Alzheimer's disease

Psychiatry Res. 1991 Nov;40(3):167-80. doi: 10.1016/0925-4927(91)90008-e.


We developed a semiautomatic method termed "cortical circumferential profiling" for objective analysis of cerebral cortex function in emission tomographic neuroimaging studies. This method treats cortex as a continuous ring near the outer brain edge. A computer algorithm samples the cortex at 60 contiguous, equiangular locations, using 1-cm2 samples. These values are plotted as a function of cortical angle to produce the cortical circumferential profile. This method was used in a study of regional cerebral perfusion in 15 patients with Alzheimer's disease and 8 elderly control subjects using N-isopropyl[I-123]-iodoamphetamine. Cortical circumferential profiling decreases variability, examines the entire cortex within slices at preselected levels above the orbital-meatal line, and facilitates intrasubject and intersubject comparisons.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Alzheimer Disease / diagnostic imaging*
  • Brain Mapping
  • Cerebral Cortex / blood supply*
  • Cerebral Cortex / diagnostic imaging
  • Dominance, Cerebral / physiology
  • Female
  • Humans
  • Male
  • Regional Blood Flow / physiology
  • Tomography, Emission-Computed, Single-Photon*