Mouse models of diabetic neuropathy

Neurobiol Dis. 2007 Dec;28(3):276-85. doi: 10.1016/j.nbd.2007.07.022. Epub 2007 Jul 31.


Diabetic neuropathy (DN) is a debilitating complication of type 1 and type 2 diabetes. Rodent models of DN do not fully replicate the pathology observed in human patients. We examined DN in streptozotocin (STZ)-induced [B6] and spontaneous type 1 diabetes [B6Ins2(Akita)] and spontaneous type 2 diabetes [B6-db/db, BKS-db/db]. Despite persistent hyperglycemia, the STZ-treated B6 and B6Ins2(Akita) mice were resistant to the development of DN. In contrast, DN developed in both type 2 diabetes models: the B6-db/db and BKS-db/db mice. The persistence of hyperglycemia and development of DN in the B6-db/db mice required an increased fat diet while the BKS-db/db mice developed severe DN and remained hyperglycemic on standard mouse chow. Our data support the hypothesis that genetic background and diet influence the development of DN and should be considered when developing new models of DN.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • DNA Fragmentation
  • Diabetic Neuropathies / chemically induced
  • Diabetic Neuropathies / classification
  • Diabetic Neuropathies / genetics*
  • Diabetic Neuropathies / physiopathology*
  • Disease Models, Animal*
  • Hyperalgesia / etiology
  • In Situ Nick-End Labeling / methods
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred DBA
  • Mice, Inbred NOD / genetics
  • Nerve Fibers / pathology
  • Neural Conduction / physiology
  • Pain Measurement
  • Reaction Time
  • Streptozocin
  • Tyrosine / analogs & derivatives
  • Tyrosine / metabolism
  • Ubiquitin Thiolesterase / metabolism


  • 3-nitrotyrosine
  • Tyrosine
  • Streptozocin
  • Ubiquitin Thiolesterase
  • Uchl1 protein, mouse