Involvement of the amygdala in the memory-enhancing effects of clenbuterol

Psychopharmacology (Berl). 1991;104(4):541-4. doi: 10.1007/BF02245663.

Abstract

Male Sprague Dawley rats with stria terminalis (ST) or sham lesions were trained in an inhibitory avoidance task, injected immediately post-training with clenbuterol hydrochloride (0.03 mg/kg; IP), and tested for retention 48 h later. Clenbuterol enhanced retention of the sham-lesioned animals but did not affect retention of the ST-lesioned animals. Clenbuterol injected intraamygdally immediately after training also enhanced retention of the inhibitory avoidance task. These results agree with other evidence suggesting the participation of beta-noradrenergic mechanisms in the amygdala in the modulation of memory storage.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amygdala / anatomy & histology
  • Amygdala / physiology*
  • Animals
  • Avoidance Learning / drug effects
  • Catheterization
  • Clenbuterol / pharmacology*
  • Dose-Response Relationship, Drug
  • Male
  • Memory / drug effects*
  • Rats
  • Rats, Inbred Strains

Substances

  • Clenbuterol