Uterine estrogen receptor binding of catecholestrogens and of estetrol (1,3,5(10)-estratriene-3,15alpha,16alpha,17beta-tetrol)

Steroids. 1976 Mar;27(3):325-33. doi: 10.1016/0039-128x(76)90054-4.


The binding affinities for the catecholestrogen metabolites of estradiol and of their methyl ethers for the rat uterine cytosol estrogen receptors were examined. Similarly the binding of the fetal estradiol metabolite, 15alpha-hydroxyestriol (estertrol) was also measured. All of the catecholestrogens showed binding affinities far in excess of their uterotrophic potency. This is different from estriol, the product of the alternative metabolic pathways and suggests that the direction of estradiol metabolism may have an important role in the modulation of estrogenic activity of the female sex hormone.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Binding Sites
  • Binding, Competitive
  • Catechols / metabolism*
  • Chromatin / metabolism
  • Cytosol / metabolism
  • Estetrol / metabolism*
  • Estradiol / analogs & derivatives*
  • Estradiol / metabolism
  • Estriol / analogs & derivatives*
  • Female
  • Kinetics
  • Liver / metabolism
  • Protein Binding
  • Rats
  • Receptors, Cell Surface*
  • Uterus / metabolism*


  • Catechols
  • Chromatin
  • Receptors, Cell Surface
  • Estradiol
  • Estetrol
  • Estriol