Octamania: the POU factors in murine development

Trends Genet. 1991 Oct;7(10):323-9. doi: 10.1016/0168-9525(91)90422-m.


Much effort has been directed towards the investigation of regulatory processes in the early mouse embryo. Several multigene families of developmental control genes have been identified. The POU family is a group of related transcription factors containing a particular type of bipartite DNA-binding domain. Members of this family show distinct expression patterns during embryonic development. Two members, Oct-4 and Oct-6, are expressed as early as in the preimplantation embryo and thus may regulate early events of murine development.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • DNA-Binding Proteins / genetics
  • Embryonic and Fetal Development / genetics*
  • Humans
  • Mice
  • Molecular Sequence Data
  • Octamer Transcription Factor-3
  • Octamer Transcription Factor-6
  • Transcription Factors / genetics
  • Transcription Factors / metabolism*


  • DNA-Binding Proteins
  • Octamer Transcription Factor-3
  • POU3F1 protein, human
  • POU5F1 protein, human
  • Pou3f1 protein, mouse
  • Pou5f1 protein, mouse
  • Transcription Factors
  • Octamer Transcription Factor-6