Boundary functions in the control of gene expression

Trends Genet. 1991 Oct;7(10):335-40. doi: 10.1016/0168-9525(91)90424-o.

Abstract

Recent experiments using stably transformed genes in mouse and Drosophila have demonstrated that elimination of euchromatic position effects can be used as a functional assay for domain boundaries. These studies will lead to an analysis of boundary structure, and in addition will provide clues to the mechanism(s) of gene regulation by higher order chromatin packaging.

Publication types

  • Review

MeSH terms

  • Animals
  • Enhancer Elements, Genetic
  • Gene Expression Regulation*
  • Promoter Regions, Genetic