Fat-soluble vitamins in infants identified by cystic fibrosis newborn screening

Pediatr Pulmonol Suppl. 1991;7:52-5. doi: 10.1002/ppul.1950110711.

Abstract

Fat-soluble vitamin status was assessed in 36 infants diagnosed with cystic fibrosis by newborn screening in the Colorado Program. At the time of diagnosis of cystic fibrosis, 36% of infants were hypoalbuminemic, 21% had vitamin A deficiency, 35% had vitamin D deficiency, and 38% had vitamin E deficiency. None had vitamin K deficiency. Supplementation with pancreatic enzymes, a multiple vitamin preparation, and additional vitamin E was associated with normalization of serum albumin, retinol, and 25-hydroxyvitamin D and negative PIVKA testing at age 6 and 12 months. Several patients remained vitamin E deficient, but this was felt to be due to poor compliance. Biochemical evidence of fat-soluble vitamin deficiency is common before age 3 months in infants with CF and responds to supplementation in the first year of life.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Cystic Fibrosis / complications
  • Cystic Fibrosis / drug therapy
  • Cystic Fibrosis / prevention & control*
  • Humans
  • Infant
  • Infant, Newborn
  • Neonatal Screening*
  • Pancreatin / therapeutic use
  • Vitamin A Deficiency / drug therapy
  • Vitamin A Deficiency / etiology*
  • Vitamin D Deficiency / drug therapy
  • Vitamin D Deficiency / etiology*
  • Vitamin E / therapeutic use
  • Vitamin E Deficiency / drug therapy
  • Vitamin E Deficiency / etiology*
  • Vitamins / therapeutic use

Substances

  • Vitamins
  • Vitamin E
  • Pancreatin