Eating fast leads to insulin resistance: findings in middle-aged Japanese men and women

Prev Med. 2008 Feb;46(2):154-9. doi: 10.1016/j.ypmed.2007.07.031. Epub 2007 Aug 3.


Objective: To examine relationships between speed of eating and insulin resistance.

Methods: Cross-sectional study of 2704 male (mean age and BMI: 48.2 y and 23.3 kg/m(2)) and 761 female (46.3 y and 21.8 kg/m(2)) non-diabetic Japanese civil servants, 75% clerical, and 25% manual laborers, using a two-part questionnaire on life-style factors and diet history with self-assessment of categorical speed of eating and energy intake over a 1-month period. We measured BMI, blood glucose and insulin concentrations and calculated insulin resistance using the homeostasis model assessment of insulin resistance: (HOMA-IR).

Results: BMI correlated with eating rate in both sexes, and with daily energy intake in men. Multiple regression analysis of log HOMA-IR by categorical speed of eating, adjusting for age, energy intake and lifestyle factors showed a statistically significant gradual increase in HOMA-IR with increases in relative eating rate in men (p<0.001, for trend) and in women (p<0.01). Adjusting for BMI, this positive relationship appeared only in men (p=0.03).

Conclusions: Our results suggest that eating fast is independently associated with insulin resistance in middle-aged Japanese men and women.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Blood Glucose / analysis
  • Body Mass Index
  • Cross-Sectional Studies
  • Energy Intake
  • Feeding Behavior / physiology*
  • Female
  • Humans
  • Insulin / analysis
  • Insulin / blood
  • Insulin Resistance / physiology*
  • Japan
  • Male
  • Middle Aged
  • Obesity
  • Surveys and Questionnaires
  • Time Factors


  • Blood Glucose
  • Insulin