Abstract
Telomeres and telomerase represent, at least in theory, an extremely attractive target for cancer therapy. The objective of this review is to present the latest view on the mechanism(s) of action of telomerase inhibitors, with an emphasis on a specific class of telomere ligands called G-quadruplex ligands, and to discuss their potential use in oncology.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Antineoplastic Agents / metabolism
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Antineoplastic Agents / pharmacology
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Antineoplastic Agents / therapeutic use
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DNA Damage / drug effects
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / metabolism*
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Enzyme Inhibitors / pharmacology
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Enzyme Inhibitors / therapeutic use
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G-Quadruplexes
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Humans
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Ligands
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Neoplasms / drug therapy
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Neoplasms / enzymology
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Neoplasms / metabolism
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Shelterin Complex
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Telomerase / antagonists & inhibitors*
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Telomerase / metabolism*
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Telomere / drug effects
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Telomere / metabolism*
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Telomere-Binding Proteins / metabolism
Substances
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Antineoplastic Agents
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Enzyme Inhibitors
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Ligands
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Shelterin Complex
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Telomere-Binding Proteins
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Telomerase