From Inflammasomes to Fevers, Crystals and Hypertension: How Basic Research Explains Inflammatory Diseases

Trends Mol Med. 2007 Sep;13(9):381-8. doi: 10.1016/j.molmed.2007.07.005. Epub 2007 Sep 5.

Abstract

Pattern-recognition receptors, such as Toll-like receptors and NOD-like receptors (NLRs), are able through the recognition of pathogen-associated molecular patterns and danger-associated molecular patterns to sense microbe-dependent and microbe-independent danger and thereby initiate innate immune responses. In some autoinflammatory conditions, abnormalities in NLR signaling pathways are involved in pathogenesis, as exemplified by NOD2 mutations associated with Crohn's disease. Some other NLRs are components of the inflammasome, a caspase-1- and prointerleukin-1beta-activating complex. Clinical and experimental studies are beginning to reveal the central role of the inflammasome in innate immunity. Here, we focus on monogenic hereditary inflammatory diseases, such as Muckle-Wells syndrome, which are associated with mutations in proteins that modulate the activity of the inflammasome, and on some multifactorial disorders, such as Type 2 diabetes and hypertension.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Diabetes Mellitus, Type 2 / immunology
  • Diabetes Mellitus, Type 2 / metabolism
  • Diabetes Mellitus, Type 2 / pathology
  • Fever / immunology*
  • Fever / metabolism
  • Humans
  • Hypertension / immunology*
  • Hypertension / metabolism
  • Hypertension / pathology
  • Inflammation / immunology
  • Inflammation / metabolism
  • Inflammation / pathology
  • Models, Biological
  • Nod Signaling Adaptor Proteins / chemistry
  • Nod Signaling Adaptor Proteins / immunology*
  • Nod Signaling Adaptor Proteins / metabolism

Substances

  • Nod Signaling Adaptor Proteins