4-Aminobiphenyl-hemoglobin adduct formation as an index of in vivo N-oxidation by hepatic cytochrome P-450IA2

Chem Res Toxicol. Mar-Apr 1991;4(2):144-7. doi: 10.1021/tx00020a003.
No abstract available

Publication types

  • Letter

MeSH terms

  • Aminobiphenyl Compounds / metabolism
  • Animals
  • Cytochrome P-450 CYP1A2
  • Cytochrome P-450 Enzyme System / biosynthesis
  • Cytochrome P-450 Enzyme System / metabolism*
  • Enzyme Activation
  • Enzyme Induction
  • Hemoglobins / biosynthesis*
  • Hemoglobins / metabolism
  • Liver / enzymology*
  • Male
  • Naphthalenes / pharmacology
  • Oxidation-Reduction
  • Oxidoreductases / biosynthesis
  • Oxidoreductases / metabolism*
  • Rats
  • Rats, Inbred Strains
  • Safrole / pharmacology

Substances

  • Aminobiphenyl Compounds
  • Hemoglobins
  • Naphthalenes
  • hemoglobin, 4-aminobiphenyl-
  • 4-biphenylamine
  • 2-ethynylnaphthalene
  • Cytochrome P-450 Enzyme System
  • Oxidoreductases
  • Cytochrome P-450 CYP1A2
  • Safrole
  • isosafrole