The effect of miswak extract on plaque pH. An in vivo study

Caries Res. 2007;41(6):451-4. doi: 10.1159/000107931. Epub 2007 Sep 7.


The aim of this study was to document changes in plaque pH when an acidic challenge was followed by rinsing with miswak extract (Salvadora persica), and to evaluate the effect of miswak rinse on parotid gland secretion rate. Plaque pH was measured in 3-day-old plaque using the microtouch electrode. Rinsing with miswak extract, compared with water rinsing, resulted in protracted elevation of plaque pH (>6.0). The difference in plaque pH between miswak extract and water rinse was statistically significant at 30 min (p < 0.001). Rinsing with miswak extract stimulated parotid gland secretion (p < 0.01). In conclusion, miswak extract raised the plaque pH, suggesting a potential role in caries prevention.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Analysis of Variance
  • Cariostatic Agents / pharmacology
  • DMF Index
  • Dental Caries / prevention & control
  • Dental Plaque / chemistry*
  • Female
  • Humans
  • Hydrogen-Ion Concentration / drug effects
  • Male
  • Middle Aged
  • Mouthwashes / pharmacology*
  • Parotid Gland / drug effects*
  • Salivation / drug effects*
  • Salvadoraceae*
  • Secretory Rate / drug effects


  • Cariostatic Agents
  • Mouthwashes