T cell therapies

Ernst Schering Found Symp Proc. 2006;(4):69-82. doi: 10.1007/2789_2007_039.


T cell therapies are increasingly used for the treatment of malignancies and viral-associated diseases. Initial studies focused on the use of unmanipulated T cell populations after allogeneic stem cell transplantation. More recently, the use of antigen-specific T cells has been explored. This chapter reviews the clinical experience with polyclonal Epstein-Barr virus (EBV)-specific cytotoxic T cells (CTL) for the treatment of EBV-associated malignancies. Strategies on how to improve the antitumor activity of EBV-specific CTL are being discussed. If effective, these strategies will have broad implications for T cell therapies for a range of human tumors with defined antigens.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Herpesvirus 4, Human
  • Hodgkin Disease / therapy
  • Humans
  • Immunotherapy, Adoptive*
  • Lymphoproliferative Disorders / therapy
  • Nasopharyngeal Neoplasms / therapy
  • T-Lymphocytes / immunology*
  • T-Lymphocytes, Cytotoxic / immunology
  • Virus Latency