The first 100 consecutive Genesis II (Smith & Nephew; Memphis, Tenn) total knee replacements (TKR) procedures performed in 97 patients by the senior investigators (RBB, RSL) had a Kaplan-Meier survivorship of 96% +/- 2% at 12 years with any reoperation as the endpoint. Significant improvements in health-related quality-of-life outcome measures were noted. There were no revisions for implant-related factors (ie, polyethylene wear, osteolysis, or aseptic loosening). No implant demonstrated radiographic loosening. The features of this device are discussed as well as its long-term performance.