Rapid human immunodeficiency virus-1 testing on labor and delivery in 17 US hospitals: the MIRIAD experience

Am J Obstet Gynecol. 2007 Sep;197(3 Suppl):S72-82. doi: 10.1016/j.ajog.2007.03.067.


The objective of the study was to evaluate the feasibility, acceptability, and accuracy of rapid human immunodeficiency virus (HIV) testing during labor. The Mother-Infant Rapid Intervention at Delivery (MIRIAD) study was a prospective, multicenter study that offered voluntary, rapid HIV testing to women with undocumented HIV status at 17 hospitals in 6 cities. Of 12,481 eligible women, 74% were approached for participation and 85.5% of those approached accepted rapid HIV testing. Among 7753 women tested, MIRIAD identified 52 (0.7%) HIV-infected women. The time between obtaining the blood sample for the rapid test and reporting the results to the health care provider was shorter for hospitals utilizing point-of-care testing than in hospitals utilizing laboratory-based testing (30 minutes vs 68 minutes; P < .0001), and point-of-care testing strategies were 14 times more likely to have a short turnaround as laboratory testing strategies. Routine rapid testing during labor provides a feasible, acceptable, and accurate way to identify HIV-infected women before delivery.

Publication types

  • Evaluation Study
  • Multicenter Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Clinical Laboratory Techniques
  • Delivery, Obstetric*
  • Feasibility Studies
  • Female
  • HIV Infections / diagnosis*
  • HIV-1*
  • Hospitals*
  • Humans
  • Immunoenzyme Techniques
  • Labor, Obstetric / blood*
  • Point-of-Care Systems
  • Pregnancy
  • Prospective Studies
  • Time Factors
  • United States