Midregional pro-atrial natriuretic peptide as a prognostic marker in pneumonia

J Infect. 2007 Nov;55(5):400-7. doi: 10.1016/j.jinf.2007.07.018. Epub 2007 Sep 10.


Objective: To evaluate the usefulness of midregional pro-atrial natriuretic peptide (MR-proANP) measurement in the stratification of severity in community-acquired pneumonia.

Methods: The population studied was three hundred patients admitted to Emergency Department of a tertiary university hospital presenting clinical signs of lower respiratory tract infection, a new infiltrate on the chest radiograph and a confirmed pneumonia by clinical evolution. Patients were stratified by the Pneumonia Severity Index (PSI), by CURB-65 score and by the development of complications. Serum samples were obtained at the moment of admission and prior to antibiotic therapy, and stored until analysis. MR-proANP was measured by B.R.A.H.M.S MR-proANP KRYPTOR.

Results: Serum levels of MR-proANP increased with the severity of pneumonia, according to PSI score and CURB-65 score. Median MR-proANP levels were significantly higher (p<0.0001) in patients with high PSI risk class (IV-V) than in those with low PSI risk class (I-III). MR-proANP levels were also significantly higher (p=0.029) in those patients that developed complications or died. There was no association between MR-proANP and etiology of pneumonia and the radiographic extent.

Conclusion: We can conclude that MR-proANP measurement was helpful for individual risk assessment in patients with pneumonia admitted to the emergency department.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Atrial Natriuretic Factor / blood*
  • Community-Acquired Infections / complications
  • Community-Acquired Infections / diagnosis*
  • Community-Acquired Infections / mortality
  • Female
  • Humans
  • Lung / diagnostic imaging
  • Male
  • Pneumonia / complications
  • Pneumonia / diagnosis*
  • Pneumonia / mortality
  • Prognosis
  • Radiography
  • Severity of Illness Index


  • Atrial Natriuretic Factor