Complications of labor induction among multiparous women in a community-based hospital system

Am J Obstet Gynecol. 2007 Sep;197(3):241.e1-7; discussion 322-3, e1-4. doi: 10.1016/j.ajog.2006.12.027.


Objective: The purpose of this study was to examine complications of labor induction compared to spontaneous labor in multiparas.

Study design: This was a retrospective cohort study of multiparous women with live, singleton pregnancies at term, who had no contraindications to labor or labor induction. Cesarean delivery was the primary outcome.

Results: Of the study subjects, 7208 experienced spontaneous labor, 2190 underwent labor induction with oxytocin, and 239 underwent labor induction requiring cervical ripening agents. Oxytocin-induced multiparas were 37% more likely to require cesarean compared to those with spontaneous labor (OR, 1.37; 95% CI, 1.10-1.71) and nearly 3 times more likely to undergo cesarean when cervical ripening agents were used (OR, 2.82; 95% CI, 1.84-4.53). Women requiring cervical ripening were also 10 times more likely to spend more than 12 hours in labor than those with spontaneous labor.

Conclusion: Multiparas undergoing labor induction are at increased risk for obstetric complications compared to spontaneous labor.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Cervical Ripening / drug effects
  • Cesarean Section
  • Female
  • Hospitals, Community
  • Humans
  • Infant, Newborn
  • Labor, Induced / adverse effects*
  • Labor, Induced / methods
  • Labor, Obstetric*
  • Male
  • Oxytocics / pharmacology
  • Oxytocics / therapeutic use*
  • Oxytocin / pharmacology
  • Oxytocin / therapeutic use*
  • Parity
  • Pregnancy
  • Pregnancy Outcome
  • Reproductive Control Agents / therapeutic use
  • Retrospective Studies


  • Oxytocics
  • Reproductive Control Agents
  • Oxytocin