Anti-inflammation activities of essential oil and its constituents from indigenous cinnamon (Cinnamomum osmophloeum) twigs

Bioresour Technol. 2008 Jun;99(9):3908-13. doi: 10.1016/j.biortech.2007.07.050. Epub 2007 Sep 10.

Abstract

In this study, chemical compositions of hydrodistilled essential oil and anti-inflammatory activities from the twigs of Cinnamomum osmophloeum Kaneh. were investigated for the first time. The chemical constituents of the twig essential oil were further analyzed by GC-MS and they were found to be L-bornyl acetate (15.89%), caryophyllene oxide (12.98%), gamma-eudesmol (8.03%), beta-caryophyllene (6.60%), T-cadinol (5.49%), delta-cadinene (4.79%), trans-beta-elemenone (4.25%), cadalene (4.19%), and trans-cinnamaldehyde (4.07%). The effects of essential oil on nitric oxide (NO) and prostaglandin E2 (PGE2) production in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages were also examined. Results of nitric oxide tests indicated that twig essential oil and its major constituents such as trans-cinnamaldehyde, caryophyllene oxide, L-borneol, L-bornyl acetate, eugenol, beta-caryophyllene, E-nerolidol, and cinnamyl acetate have excellent activities. These findings demonstrated that essential oil of C. osmophloeum twigs have excellent anti-inflammatory activities and thus have great potential to be used as a source for natural health products.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acrolein / analogs & derivatives
  • Acrolein / pharmacology
  • Animals
  • Anti-Inflammatory Agents / pharmacology*
  • Cell Death / drug effects
  • Cell Line
  • Cinnamomum / chemistry*
  • Cinnamomum / drug effects
  • Curcumin / pharmacology
  • Dinoprostone / biosynthesis
  • Humans
  • Lipopolysaccharides / pharmacology
  • Mice
  • Nitric Oxide / biosynthesis
  • Oils, Volatile / chemistry
  • Oils, Volatile / pharmacology*

Substances

  • Anti-Inflammatory Agents
  • Lipopolysaccharides
  • Oils, Volatile
  • Nitric Oxide
  • Acrolein
  • Curcumin
  • Dinoprostone
  • cinnamic aldehyde