HLA-B40: a marker for susceptibility to lung disease in rheumatoid arthritis

Dis Markers. Mar-Apr 1991;9(2):97-101.


We have compared the frequency of HLA antigens in groups of patients with rheumatoid arthritis (RA) who had pulmonary manifestations, other extra-articular features or articular disease alone. There was a significantly increased frequency of the antigen HLA-B40 in patients with lung involvement compared to other forms of extra-articular RA (relative risk 40.54), and when compared to the total RA group (relative risk 4.94). In contrast there was little variation in the frequency of HLA-DR4, which was significantly increased in all patient groups. These data suggest that HLA-B40 is a marker of increased susceptibility to lung disease in patients with rheumatoid arthritis.

Publication types

  • Comparative Study

MeSH terms

  • Arthritis, Rheumatoid / complications*
  • Arthritis, Rheumatoid / genetics
  • Arthritis, Rheumatoid / immunology
  • Biomarkers
  • Disease Susceptibility / immunology
  • Female
  • HLA-B Antigens / analysis*
  • HLA-B40 Antigen
  • Humans
  • Lung Diseases / complications
  • Lung Diseases / genetics*
  • Lung Diseases / immunology
  • Male
  • Reference Values


  • Biomarkers
  • HLA-B Antigens
  • HLA-B40 Antigen