Effect of Vaccinium ashei reade leaves on angiotensin converting enzyme activity in vitro and on systolic blood pressure of spontaneously hypertensive rats in vivo

Biosci Biotechnol Biochem. 2007 Sep;71(9):2335-7. doi: 10.1271/bbb.70277. Epub 2007 Sep 7.


The hypotensive effects of Vaccinium ashei reade (blueberry) leaves were studied in vitro and in vivo. Blueberry leaf showed a strong inhibitory effect on angiotensin-converting enzyme activity in vitro. Additionally, feeding of blueberry leaf suppressed the development of essential hypertension in spontaneously hypertensive rats in vivo. These results promise the use of blueberry leaf as a source of dietary hypotensive components.

MeSH terms

  • Angiotensin-Converting Enzyme Inhibitors / chemistry*
  • Angiotensin-Converting Enzyme Inhibitors / pharmacology*
  • Animals
  • Blood Pressure / drug effects*
  • Blueberry Plants / chemistry*
  • Body Weight / drug effects
  • Peptidyl-Dipeptidase A / metabolism*
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology
  • Plant Leaves / chemistry
  • Rats


  • Angiotensin-Converting Enzyme Inhibitors
  • Plant Extracts
  • Peptidyl-Dipeptidase A