COUP-TFI regulates the balance of cortical patterning between frontal/motor and sensory areas

Nat Neurosci. 2007 Oct;10(10):1277-86. doi: 10.1038/nn1958. Epub 2007 Sep 9.


We used cortex-specific deletion of the transcription factor gene COUP-TFI (also known as Nr2f1) in mice to demonstrate previously unknown fundamental roles for it in patterning mammalian neocortex into areas. The highest COUP-TFI expression is observed in the cortical progenitors and progeny in parietal and occipital cortex that form sensory areas, and the lowest expression was observed in frontal cortex that includes motor areas. Cortical deletion of COUP-TFI resulted in massive expansion of frontal areas, including motor, to occupy most of neocortex, paralleled by marked compression of sensory areas to caudal occipital cortex. These area patterning changes are preceded and paralleled by corresponding changes in molecular markers of area identity and altered axonal projections to maintain patterned area-specific input and output connections. We conclude that COUP-TFI is required for balancing patterning of neocortex into frontal/motor and sensory areas by acting in its expression domain to repress frontal/motor area identities and to specify sensory area identities.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Body Patterning / genetics
  • Body Patterning / physiology*
  • COUP Transcription Factor I / genetics
  • COUP Transcription Factor I / physiology*
  • Embryo, Mammalian
  • Fibroblast Growth Factor 8 / metabolism
  • Gene Expression Regulation, Developmental / physiology*
  • Homeodomain Proteins / metabolism
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Motor Cortex / cytology
  • Motor Cortex / embryology*
  • Motor Cortex / metabolism
  • Neural Pathways / cytology
  • Neural Pathways / embryology
  • Neural Pathways / metabolism
  • PAX2 Transcription Factor / metabolism
  • Serotonin / metabolism
  • Somatosensory Cortex / embryology*
  • Somatosensory Cortex / metabolism
  • Transcription Factors / metabolism


  • COUP Transcription Factor I
  • Fgf8 protein, mouse
  • Homeodomain Proteins
  • PAX2 Transcription Factor
  • Pax2 protein, mouse
  • Transcription Factors
  • empty spiracles homeobox proteins
  • Fibroblast Growth Factor 8
  • Serotonin