Effect of excessive iodine on immune function of lymphocytes and intervention with selenium

J Huazhong Univ Sci Technolog Med Sci. 2007 Aug;27(4):422-5. doi: 10.1007/s11596-007-0418-1.


In order to study the effect of excessive iodine on immune function of lymphocytes and the role of selenium supplementation with excessive iodine intake, the changes of T lymphocyte number, ratio of subsets, activity of natural killer (NK) cells and lymphocytes proliferation response were investigated. 150 female BALB/C mice were randomly divided into 5 groups in terms of their body weight (n=30 in each group), and 10 of each group were taken as one batch for test. Mice in the 5 groups were orally administrated with iodine 0 (group I), 1500 (group II), 3000 (group III), 6000 microg/L (group IV), iodine 6000 microg/L plus selenium 0.3 mg/L (group V) respectively for 30 days Lymphocyte proliferation response, CD4(+)/CD8(+), Th1/Th2 and the activity of NK cells were measured. CD4(+)/CD8(+) was significantly lower, while lymphocyte proliferation response stronger, and Th1/Th2 and the activity of NK cells significantly higher in group IV than in group I (P<0.01). There was no significant difference in all indexes between group V and group I (P>0.05). It was suggested that excessive iodine as exogenous chemical materials can induce disorders of T lymphocyte immune function in mice. 0.3 mg/L selenium supplementation can protect mice against toxicity induced by 6000 microg/L iodine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • CD4-CD8 Ratio
  • Cell Proliferation / drug effects
  • Female
  • Iodine / administration & dosage*
  • Iodine / adverse effects
  • Iodine / antagonists & inhibitors*
  • Killer Cells, Natural / immunology
  • Lymphocytes / cytology
  • Lymphocytes / immunology*
  • Mice
  • Mice, Inbred BALB C
  • Random Allocation
  • Selenium / pharmacology*
  • Th1 Cells / immunology
  • Th2 Cells / immunology


  • Iodine
  • Selenium