Molecular genetic studies of major histocompatibility complex genes in children with juvenile dermatomyositis: increased risk associated with HLA-DQA1 *0501

Hum Immunol. 1991 Dec;32(4):235-40. doi: 10.1016/0198-8859(91)90085-n.

Abstract

Juvenile dermatomyositis (JDMS) is an inflammatory disease associated with HLA-DR3. We therefore undertook molecular genetic studies of HLA region genes to determine whether HLA-DR3 itself confers susceptibility to JDMS or whether susceptibility is conferred by alleles in linkage disequilibrium with HLA-DR3. Our results indicate that JDMS is associated with the HLA-DQA1 allele DQA1 *0501 on non-DR3 haplotypes in Caucasian JDMS. Furthermore, the reported of association between the C4A gene deletion and JDMS is likely due to linkage disequilibrium with HLA-DR3.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Alleles
  • Child
  • Child, Preschool
  • DNA / analysis
  • Dermatomyositis / genetics*
  • Disease Susceptibility
  • Electrophoresis, Agar Gel
  • Female
  • Genes, MHC Class II / genetics*
  • HLA-DQ Antigens / genetics*
  • HLA-DQ alpha-Chains
  • HLA-DR3 Antigen / genetics
  • Humans
  • Infant
  • Linkage Disequilibrium
  • Male
  • Molecular Biology
  • Polymerase Chain Reaction
  • Risk Factors

Substances

  • HLA-DQ Antigens
  • HLA-DQ alpha-Chains
  • HLA-DQA1 antigen
  • HLA-DR3 Antigen
  • DNA