Some metabolic relationships between biopterin and folate: implications for the "methyl trap hypothesis"

Neurochem Res. 1991 Sep;16(9):1031-6. doi: 10.1007/BF00965847.


Tetrahydrobiopterin and the folate coenzymes can reciprocally interact in ways that would be useful to the metabolic pathways subserved by both of these coenzymes. Thus, through one of the reactions catalyzed by methylene tetrahydrofolate reductase, 5-CH3-H4-folate can regenerate BH4 from q-BH2 and q-BH2 can provide an escape from the "methyl trap."

Publication types

  • Comparative Study
  • Review

MeSH terms

  • 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase / metabolism*
  • Animals
  • Biopterin / metabolism*
  • Folic Acid / metabolism*


  • Biopterin
  • Folic Acid
  • 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase