Fluoroacetate and fluorocitrate: mechanism of action

Neurochem Res. 1991 Sep;16(9):1055-8. doi: 10.1007/BF00965850.


The concept of lethal synthesis as suggested by Peters is reviewed in the light of the more recent work in this area. It is suggested that fluorocitrate is a "suicide" substrate for aconitase rather than a competitive inhibitor as originally suggested. The use of these substances to study glial-neuronal relationships is considered.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Aconitate Hydratase / metabolism*
  • Animals
  • Citrates / toxicity*
  • Fluoroacetates / metabolism*
  • Neuroglia / drug effects
  • Neurons / drug effects


  • Citrates
  • Fluoroacetates
  • fluorocitrate
  • Aconitate Hydratase