Hyperalgesia and myoclonus with intrathecal infusion of high-dose morphine

Pain. 1991 Dec;47(3):337-9. doi: 10.1016/0304-3959(91)90225-m.


We report the case of a patient who developed myoclonus and hyperalgesia following administration of high-dose subarachnoid morphine. This complication occurred with 40-80 mg/day continuous infusion. The pathophysiology of these side effects is discussed.

Publication types

  • Case Reports

MeSH terms

  • Drug Administration Schedule
  • Humans
  • Hyperalgesia / chemically induced*
  • Injections, Spinal
  • Male
  • Middle Aged
  • Morphine / administration & dosage
  • Morphine / adverse effects*
  • Myoclonus / chemically induced*


  • Morphine