Regulation of angiogenesis and vascular permeability by Src family kinases: opportunities for therapeutic treatment of solid tumors

Expert Opin Ther Targets. 2007 Sep;11(9):1207-17. doi: 10.1517/14728222.11.9.1207.


Aberrant expression or activation of protein tyrosine kinases, including Src and related Src family kinases, is a common occurrence in many human cancers, resulting in deregulation of expression of numerous mediators of cellular functions, including pro-angiogenic molecules. In addition, Src activation regulates vascular permeability of endothelial cells. How these processes contribute to tumor progression and metastasis are the subjects of this review. As Src-selective inhibitors have entered clinical trials for a number of solid tumors, further understanding of the roles of Src kinases in mediating tumor angiogenesis as well as modulating tumor/microenvironment interactions will provide insights into the best use of these inhibitors in treating patients afflicted with tumors in which Src is activated.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Capillary Permeability
  • Endothelial Cells / physiology
  • Humans
  • Neoplasms / drug therapy
  • Neoplasms / enzymology*
  • Neoplasms / pathology
  • Neovascularization, Pathologic
  • Vascular Endothelial Growth Factor A / metabolism
  • src-Family Kinases / antagonists & inhibitors
  • src-Family Kinases / metabolism*


  • Vascular Endothelial Growth Factor A
  • src-Family Kinases