Combined double lung-liver transplantation for cystic fibrosis without cardio-pulmonary by-pass

Am J Transplant. 2007 Oct;7(10):2433-8. doi: 10.1111/j.1600-6143.2007.01945.x.


Sequential bilateral single lung-liver transplantation (SBSL-LTx) is a therapeutic option for patients with end stage lung and liver disease (ESLLD) due to cystic fibrosis (CF). A few cases have been reported, all of them were performed with the use of cardio-pulmonary by-pass (CPB). We performed SBSL-LTx in three young men affected by CF. All the recipients had respiratory failure and portal hypertension with hypersplenism. Along with lung transplants, two patients received a whole liver graft and one an extended right graft from an in situ split liver. During transplantation neither CPB nor veno-venous by-pass (VVB) were employed. Immunosuppression was based on basiliximab, tacrolimus, steroids and azathioprine. The three recipients are alive with a median follow-up of 670 days (range 244-1,533). Combined SBSL-LTx is a complex but effective procedure for the treatment of ESLLD due to CF, not necessarily requiring the use of CPB or VVB.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Cardiopulmonary Bypass*
  • Cystic Fibrosis / complications*
  • Cystic Fibrosis / surgery*
  • Humans
  • Intraoperative Period
  • Liver Failure / etiology
  • Liver Failure / surgery*
  • Liver Transplantation / methods*
  • Lung Diseases / etiology
  • Lung Diseases / surgery*
  • Lung Transplantation / methods*
  • Male
  • Treatment Outcome