The polymorphisms of Eotaxin 1 and CCR3 genes influence on serum IgE, Eotaxin levels and mild asthmatic children in Taiwan

Allergy. 2007 Oct;62(10):1125-30. doi: 10.1111/j.1398-9995.2007.01485.x.


Background: Asthma is a complex disorder, which is known to be affected by interactions between genetic and environmental factors. The human Eotaxin 1 and CCR3 attract eosinophils and Th2-lymphocytes to migrate to the inflammatory foci that could represent a key mechanism in allergy and asthma.

Objective: We hypothesized that Eotaxin1 gene Ala23Thr and A-384 G, and CCR3 gene T51C polymorphisms are associated with plasma Eotaxin levels and predispose individuals to asthma pathogenesis.

Methods: One hundred seventy-eight hospital-based asthmatic children and 277 community-based controls aged from 5 to 12 years were recruited in southern Taiwan. Whole blood samples and questionnaires were collected. In this study, we addressed genetic effects of Eotaxin 1 and CCR3 genes on asthma, plasma IgE and Eotaxin 1 levels.

Results: In comparison with subjects with Ala23Ala genotype, Ala23Thr polymorphism of the Eotaxin 1 gene showed a significant protective effect on asthma (AOR = 0.58, 95% CI = 0.37-0.92). We demonstrated that the mean Eotaxin 1 concentration was significantly higher in subjects with Ala23Ala than in subjects with Thr23Thr (P = 0.005) or Ala23Thr (P = 0.07), which showed a gene-dose dependent relationship. But, we observed that the A-384G polymorphism of Eotaxin 1 gene and T51C polymorphism of CCR3 gene are not associated with asthma.

Conclusion: This study finding provide a strong evidence that Eotaxin 1 Thr23Thr homozygote has a protective effect on asthma and significantly decreases plasma Eotaxin 1 concentrations in asthmatics in Taiwan.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Asthma / genetics*
  • Asthma / immunology*
  • Chemokine CCL11 / blood*
  • Chemokine CCL11 / genetics*
  • Child
  • Child, Preschool
  • DNA / blood
  • DNA / isolation & purification
  • Eosinophils / immunology
  • Eosinophils / metabolism
  • Female
  • Gene Frequency / immunology
  • Genetic Predisposition to Disease / genetics
  • Genotype
  • Humans
  • Immunoglobulin E / blood*
  • Male
  • Polymorphism, Genetic / genetics*
  • Polymorphism, Genetic / immunology
  • Polymorphism, Restriction Fragment Length / genetics
  • Polymorphism, Restriction Fragment Length / immunology
  • Polymorphism, Single Nucleotide / genetics
  • Polymorphism, Single Nucleotide / immunology
  • Receptors, CCR3 / genetics*
  • Receptors, CCR3 / metabolism
  • Reference Values
  • Severity of Illness Index
  • T-Lymphocytes / immunology
  • T-Lymphocytes / metabolism
  • Taiwan


  • Chemokine CCL11
  • Receptors, CCR3
  • Immunoglobulin E
  • DNA