Isatinones A and B, new antifungal oxindole alkaloids from Isatis costata

Itrat Fatima; Ijaz Ahmad; Itrat Anis; Abdul Malik; Nighat Afza

doi:10.3390/12020155

Isatinones A and B, new antifungal oxindole alkaloids from Isatis costata

Molecules. 2007 Feb 6;12(2):155-62. doi: 10.3390/12020155.

Authors

Itrat Fatima¹, Ijaz Ahmad, Itrat Anis, Abdul Malik, Nighat Afza

Affiliation

¹ International Centre for Chemical Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan.

Abstract

Two new oxindole alkaloids isatinone A (1) and B (2) have been isolated from Isatis costata, along with the known trisindoline. Their structures have been assigned on the basis of spectroscopic techniques and chemical studies. Both new compounds showed significant antifungal activity.

MeSH terms

Alkaloids / chemistry
Alkaloids / pharmacology*
Antifungal Agents / pharmacology*
Fungi / drug effects*
Indoles / chemistry
Indoles / pharmacology*
Isatis / chemistry*
Magnetic Resonance Spectroscopy
Molecular Structure
Oxindoles
Phenylacetates / chemistry
Phenylacetates / pharmacology*
Plant Extracts / pharmacology*

Substances

2-ethylhexyl 2-(4-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)(phenyl)methoxy)phenylacetate
3-(methoxy(phenyl)methylidene)-1,3-dihydro-2H-indol-2-one
Alkaloids
Antifungal Agents
Indoles
Oxindoles
Phenylacetates
Plant Extracts
2-oxindole