Emerging role of SUMO in pancreatic beta-cells

Horm Metab Res. 2007 Sep;39(9):658-64. doi: 10.1055/s-2007-985372.

Abstract

Post-translational attachment of small ubiquitin-like modifier (SUMO), defined as SUMOylation, can affect the localization, interactions, stability and/or activity of substrate proteins, and thus can participate in a large variety of cellular processes. Most SUMO substrates are involved in transcriptional regulation. Hence, SUMOylation can either activate or, more commonly, repress gene transcription. The modulation of gene expression by SUMO through diverse mechanisms and specifically the recent findings concerning SUMOylation in pancreatic beta-cells are reviewed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • DNA-Binding Proteins / metabolism
  • Diabetes Mellitus, Type 1 / genetics
  • Gene Expression Regulation / physiology
  • Genetic Predisposition to Disease
  • Homeodomain Proteins / metabolism
  • Humans
  • Insulin / genetics
  • Insulin-Secreting Cells / metabolism*
  • Maf Transcription Factors, Large / metabolism
  • Models, Biological
  • Protein Binding
  • Protein Conformation
  • Protein Processing, Post-Translational / physiology*
  • Protein Transport / physiology
  • Receptor-Like Protein Tyrosine Phosphatases, Class 8 / metabolism
  • SUMO-1 Protein / genetics
  • SUMO-1 Protein / metabolism
  • SUMO-1 Protein / physiology*
  • Saccharomyces cerevisiae
  • Signal Transduction / physiology
  • Trans-Activators / metabolism

Substances

  • DNA-Binding Proteins
  • Homeodomain Proteins
  • Insulin
  • MAFA protein, human
  • Maf Transcription Factors, Large
  • SUMO-1 Protein
  • Trans-Activators
  • pancreatic and duodenal homeobox 1 protein
  • Receptor-Like Protein Tyrosine Phosphatases, Class 8