Allele-specific targeting of microRNAs to HLA-G and risk of asthma

Am J Hum Genet. 2007 Oct;81(4):829-34. doi: 10.1086/521200. Epub 2007 Aug 20.


HLA-G is a nonclassic, class I HLA molecule that has important immunomodulatory properties. Previously, we identified HLA-G as an asthma-susceptibility gene and discovered that the risk of asthma in a child was determined by both the child's HLA-G genotype and the mother's affection status. Here we report a SNP in the 3' untranslated region of HLA-G that influences the targeting of three microRNAs (miRNAs) to this gene, and we suggest that allele-specific targeting of these miRNAs accounts, at least in part, for our earlier observations on HLA-G and the risk of asthma.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • 3' Untranslated Regions
  • Alleles
  • Asthma / genetics*
  • Asthma / immunology*
  • Base Sequence
  • Binding Sites / genetics
  • Female
  • Genetic Predisposition to Disease
  • Genotype
  • HLA Antigens / genetics*
  • HLA-G Antigens
  • Histocompatibility Antigens Class I / genetics*
  • Humans
  • Linkage Disequilibrium
  • Male
  • MicroRNAs / chemistry
  • MicroRNAs / genetics*
  • MicroRNAs / metabolism
  • Polymorphism, Single Nucleotide
  • Risk Factors


  • 3' Untranslated Regions
  • HLA Antigens
  • HLA-G Antigens
  • Histocompatibility Antigens Class I
  • MicroRNAs