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Review
. 2007;315:325-44.
doi: 10.1007/978-3-540-70962-6_13.

Bats, Civets and the Emergence of SARS

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Free PMC article
Review

Bats, Civets and the Emergence of SARS

L F Wang et al. Curr Top Microbiol Immunol. .
Free PMC article

Abstract

Severe acute respiratory syndrome (SARS) was the first pandemic transmissible disease of previously unknown aetiology in the twenty-first century. Early epidemiologic investigations suggested an animal origin for SARS-CoV. Virological and serological studies indicated that masked palm civets ( Paguma larvata), together with two other wildlife animals, sampled from a live animal market were infected with SARS-CoV or a closely related virus. Recently, horseshoe bats in the genus Rhinolophus have been identified as natural reservoir of SARS-like coronaviruses. Here, we review studies by different groups demonstrating that SARS-CoV succeeded in spillover from a wildlife reservoir (probably bats) to human population via an intermediate host(s) and that rapid virus evolution played a key role in the adaptation of SARS-CoVs in at least two nonreservoir species within a short period.

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References

    1. Anderson RM, Fraser C, Ghani AC, Donnelly CA, Riley S, Ferguson NM, Leung GM, Lam TH, Hedley AJ. Epidemiology, transmission dynamics and control of SARS: the 2002–2003 epidemic. Philos Trans R Soc Lond B. 2004;359:1091–1105. doi: 10.1098/rstb.2004.1490. - DOI - PMC - PubMed
    1. Calisher CH, Childs JE, Field HE, Holmes KV, Schountz T. Bats: important reservoir hosts of emerging viruses. Clin Microbiol Rev. 2006;19:531–545. doi: 10.1128/CMR.00017-06. - DOI - PMC - PubMed
    1. Chen WJ, Yan MH, Yang L, Ding BL, He B, Wang YZ, Liu XL, Liu CH, Zhu H, You B, Huang SY, Zhang JG, Mu F, Xiang Z, Feng XL, Wen J, Fang JQ, Yu J, Yang HM, Wang J. SARS-associated coronavirus transmitted from human to pig. Emerg Inf Dis. 2005;11:446–448.
    1. Childs JE. Zoonotic viruses of wildlife: hither from yon. Arch Virol Suppl. 2004;18:1–11. - PubMed
    1. The Chinese SARS Molecular Epidemiology Consortium Molecular evolution of the SARS coronavirus during the course of the SARS epidemic in China. Science. 2004;303:1666–1669. doi: 10.1126/science.1092002. - DOI - PubMed

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