Inappropriate continuation of stress ulcer prophylactic therapy after discharge

Ann Pharmacother. 2007 Oct;41(10):1611-6. doi: 10.1345/aph.1K227. Epub 2007 Sep 11.


Background: Medications for stress ulcer prophylaxis are appropriately started in critically ill patients with risks for developing stress ulcers. It is unknown whether these drugs are discontinued once the risk factors are removed.

Objective: To assess the duration of stress ulcer prophylactic therapy in critically ill patients.

Methods: A retrospective chart review was conducted at a multidisciplinary, 24 bed medical/surgical intensive care unit (ICU) of a university-affiliated tertiary referral medical center. Three hundred ninety-four patients fulfilled eligibility criteria during the study period of July 1, 2005, through September 30, 2005. Patients were considered to be appropriately discharged from the hospital on gastric acid suppressants if they met any of the following criteria: continued mechanical ventilation, gastroesophageal reflux disease, peptic ulcer disease, history of gastrointestinal ulceration or bleeding within the past year, prescribed medications used for stress ulcer prophylaxis prior to admission, gastrointestinal bleed during hospitalization, or prescriber indication of reason to continue therapy.

Results: Three hundred fifty-seven patients received stress ulcer prophylaxis during their ICU stay. Of these, 80% continued on gastric acid suppressants on transfer from the ICU, with 60% of the therapy being inappropriate. The percentage of critically ill patients discharged from the hospital with inappropriate prescription of gastric acid suppressants was 24.4%. Based on the average wholesale cost, the total cost for unnecessary gastric acid suppressant therapy within the follow-up period was $13,973.

Conclusions: Gastric acid suppressant medications initially prescribed for stress ulcer prophylaxis are frequently prescribed inappropriately on discharge for patients who were initially admitted to the medical/surgical ICU.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Anti-Ulcer Agents / administration & dosage*
  • Cohort Studies
  • Critical Illness / epidemiology
  • Critical Illness / therapy
  • Female
  • Humans
  • Male
  • Middle Aged
  • Patient Discharge / trends*
  • Peptic Ulcer / drug therapy*
  • Peptic Ulcer / epidemiology
  • Peptic Ulcer / etiology
  • Retrospective Studies
  • Stress, Physiological / complications
  • Stress, Physiological / drug therapy*
  • Stress, Physiological / epidemiology
  • Time Factors


  • Anti-Ulcer Agents