Mild cognitive impairment in general practice: age-specific prevalence and correlate results from the German study on ageing, cognition and dementia in primary care patients (AgeCoDe)

Dement Geriatr Cogn Disord. 2007;24(4):307-16. doi: 10.1159/000108099. Epub 2007 Sep 11.


Background: Although mild cognitive impairment (MCI) represents a high-risk factor for developing dementia, little is known about the prevalence of MCI among patients of general practitioners (GPs).

Aims: Estimation of age-specific prevalence for original and modified concepts of MCI and their association with sociodemographic, medical and genetic (apoE epsilon4 genotype) factors among patients of GPs.

Methods: A GP practice sample of 3,327 individuals aged 75+ was assessed by structured clinical interviews.

Results: Prevalence was 15.4% (95% CI = 14.1-16.6) for original and 25.2% (95% CI = 23.7-26.7) for modified MCI. Rates increased significantly with older age. Positive associations were found for apoE epsilon4 allele, vascular diseases and depressive symptoms.

Conclusion: MCI is frequent in elderly patients of GPs. GPs have a key position in secondary prevention and care of incipient cognitive deterioration up to the diagnosis of dementia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Distribution
  • Aged
  • Aged, 80 and over
  • Alleles
  • Apolipoprotein E4
  • Cognition Disorders / complications
  • Cognition Disorders / epidemiology*
  • Cognition Disorders / genetics
  • Cognition Disorders / psychology*
  • Cohort Studies
  • Depression / complications
  • Family Practice / statistics & numerical data*
  • Female
  • Genotype
  • Humans
  • Male
  • Prevalence
  • Severity of Illness Index
  • Sex Distribution
  • Vascular Diseases / complications


  • Apolipoprotein E4