Pustulosis palmoplantaris (PPP) is a rare (0.01 to 0.05%), non-infectious acute or chronic skin disease which preferentially affects women in the 4th to the 6th decade of their life. The principal differential diagnosis is with infected dyshidrosis and with mycoses. Nosologically, PPP has a controversial relationship with psoriasis when it is isolated. Epidemiological and genetic data have shown that PPP and psoriasis are two nosologically close but distinct dermatoses. PPP may be associated with aseptic pustular osteoarthritis of the anterior chest wall (Sonozaki's syndrome). Modern treatment of PPP rests on photochemotherapy (PUVA), aromatic retinoids or, better, a combination of both (Reti-PUVA).