Effect of non-surgical periodontal therapy on clinical and immunological response and glycaemic control in type 2 diabetic patients with moderate periodontitis

J Clin Periodontol. 2007 Oct;34(10):835-43. doi: 10.1111/j.1600-051X.2007.01127.x.


Objectives: The purpose of this study was to compare the local efficacy of nonsurgical periodontal therapy between type 2 diabetic and non-diabetic patients and the effect of periodontal therapy on glycaemic control.

Background: A complex two-way relationship exists between diabetes mellitus and periodontitis.

Materials and methods: After selection, 20 subjects (10 diabetic and 10 non-diabetic) underwent baseline examination, periodontal clinical study and biochemical analysis of gingival crevicular fluid (GCF). After the pre-treatment phase, subgingival scaling and root planing were performed. Subsequently, all subjects continued the maintenance programme and were re-examined at 3 and 6 months.

Results: Diabetic and non-diabetic subjects responded well after therapy, showing a very similar progression during the follow-up period. Both groups showed clinically and immunologically significant improvements. Significant reductions were also found in the total volume of GCF and levels of interleukin-1beta and tumour necrosis factor-alpha. Diabetic subjects showed an improvement in their metabolic control. The change in glycosylated haemoglobin (HbA(1C)) was statistically significant at 3 and 6 months.

Conclusions: The clinical and immunological improvements obtained were accompanied by a significant reduction in HbA(1C) values in type 2 diabetic subjects. Larger studies are needed to confirm this finding and establish whether periodontal therapy has a significant effect on glycaemic control.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Case-Control Studies
  • Dental Scaling
  • Diabetes Mellitus, Type 2 / blood
  • Diabetes Mellitus, Type 2 / complications*
  • Diabetes Mellitus, Type 2 / urine
  • Epidemiologic Methods
  • Female
  • Gingival Crevicular Fluid / chemistry*
  • Glycemic Index
  • Humans
  • Interleukin-1beta / analysis*
  • Male
  • Middle Aged
  • Periodontitis / complications
  • Periodontitis / therapy*
  • Root Planing
  • Tumor Necrosis Factor-alpha / analysis*


  • Interleukin-1beta
  • Tumor Necrosis Factor-alpha