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. 2007 Jun;129(3):366-370.
doi: 10.1016/j.pain.2007.02.012.

Responses to Drs. Kim and Dionne Regarding Comments on Diatchenko, Et Al. Catechol-O-methyltransferase Gene Polymorphisms Are Associated With Multiple Pain-Evoking Stimuli. Pain 2006; 125: 216-24

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Responses to Drs. Kim and Dionne Regarding Comments on Diatchenko, Et Al. Catechol-O-methyltransferase Gene Polymorphisms Are Associated With Multiple Pain-Evoking Stimuli. Pain 2006; 125: 216-24

Luda Diatchenko et al. Pain. .
Free PMC article

Figures

Figure 1
Figure 1. Responses to the Temporal Summation of Repeated Heat Stimuli categorized by five major diplotypes of COMT
Mean visual analog scale (VAS) responses to 15 thermal pulses were plotted for five diplotypes of COMT (Panel 1A). VAS responses in the range 0-19 were truncated to 9. Data are expressed as Mean ± SEM. Adjusted mean values of temporal change in VAS among val158met genotypes were derived from the analysis of covariance models (Panel 2B). The adjusted means reveal a significant curvilinear gradient of log(pulse) which was greater for the met/met genotype compared with val/val genotype (P=0.005). Adjusted means isolated the contribution of val158met polymorphism to overall haplotype variation after controlling for effects if other SNPs in the haplotype (rs6269, rs4633 and rs4818).
Figure 2
Figure 2. Thermal pain sensitivity categorized by three major COMT haplotype combinations
Thermal pain threshold and tolerance values (°C) assessed from the skin overlying the arm, cheek and foot. Each value represents the mean and associated s.e.m. Group comparisons were performed using a one-way ANOVA followed by Bonferroni adjustment for post-hoc testing. *P < 0.05, **P < 0.01, ***P < 0.001.
Figure 3
Figure 3. Pressure pain sensitivity categorized by three major COMT haplotype combinations
Mechanical pain thresholds (kg) assessed over the temporalis and masseter muscles, the temporomandibular joint and the ventral surfaces of the wrists. Each value represents the mean and associated s.e.m. Group comparisons were performed using a one-way ANOVA followed by Bonferroni adjustment for post-hoc testing. *P < 0.05, **P < 0.01, ***P < 0.001.
Figure 4
Figure 4. Ischemic pain sensitivity categorized by three major COMT haplotype combinations
Threshold and tolerance measures (sec) to ischemic pain. Each value represents the mean and associated s.e.m. Group comparisons were performed using a one-way ANOVA followed by Bonferroni adjustment for post-hoc testing. *P < 0.05, **P < 0.01, ***P < 0.001.

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