Linear, redox modified DNA probes as electrochemical DNA sensors

Francesco Ricci; Rebecca Y Lai; Kevin W Plaxco

doi:10.1039/b708882e

Linear, redox modified DNA probes as electrochemical DNA sensors

Chem Commun (Camb). 2007 Sep 28:(36):3768-70. doi: 10.1039/b708882e. Epub 2007 Jul 5.

Authors

Francesco Ricci¹, Rebecca Y Lai, Kevin W Plaxco

Affiliation

¹ Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106, USA.

PMID: 17851622
DOI: 10.1039/b708882e

Abstract

We show here that hybridization-linked changes in the dynamics of a redox-modified, electrode-bound linear (as opposed to stem-loop) probe DNA produce large changes in Faradaic current, allowing for the ready detection of target oligonucleotides.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Biosensing Techniques / methods
DNA / analysis*
DNA Probes / chemical synthesis*
DNA Probes / chemistry
Electrochemistry
Oligodeoxyribonucleotides / analysis*

Substances

DNA Probes
Oligodeoxyribonucleotides
DNA