Serum cytokine levels in active uveitis and remission

Curr Eye Res. Jul-Aug 2007;32(7-8):669-75. doi: 10.1080/02713680701523147.

Abstract

Serum levels of interleukin(IL)-8, IL-6, and (TNF)-alpha were measured in 25 patients during active uveitis and uveitis in remission and compared to age-matched controls. Levels of IL-8 and IL-6 were significantly elevated in patients with active disease and were decreased during remission. IL-8 levels were highest in patients with anterior uveitis, with greatest difference between active disease and remission. No consistent pattern was observed for TNF-alpha. In conclusion, serum cytokine levels are elevated in active noninfectious uveitis. The rise in IL-8 may suggest innate immune mechanisms in the acute disease, while IL-6 participates in modulation of inflammation in the chronic disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Enzyme-Linked Immunosorbent Assay
  • Humans
  • Interleukin-6 / blood*
  • Interleukin-8 / blood*
  • Panuveitis / blood*
  • Tumor Necrosis Factor-alpha / analysis*
  • Uveitis, Anterior / blood*
  • Uveitis, Posterior / blood*

Substances

  • CXCL8 protein, human
  • IL6 protein, human
  • Interleukin-6
  • Interleukin-8
  • Tumor Necrosis Factor-alpha