Normal pregnancy after curative multiagent chemotherapy for choriocarcinoma with brain metastases

Acta Obstet Gynecol Scand. 1991;70(7-8):611-3. doi: 10.3109/00016349109007926.

Abstract

A case is reported of a metastatic gestational choriocarcinoma in a 25-year old woman. Extensive pelvic, pulmonary and brain metastases were associated with clinically manifest thyrotoxicosis. Multiagent chemotherapy alone was successful in achieving a durable remission and euthyroid state. The chemotherapy regimen consisted of cis-platinum, etoposide, actinomycin-D, and intrathecal methotrexate (PEA-M). The Patient conceived 2 years after completing therapy and gave birth at term to a normal infant.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects*
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Brain Neoplasms / drug therapy*
  • Brain Neoplasms / secondary*
  • Choriocarcinoma / drug therapy*
  • Choriocarcinoma / secondary*
  • Cisplatin / administration & dosage
  • Dactinomycin / administration & dosage
  • Etoposide / administration & dosage
  • Female
  • Humans
  • Lung Neoplasms / drug therapy
  • Lung Neoplasms / secondary
  • Methotrexate / administration & dosage
  • Pregnancy Complications, Neoplastic / drug therapy*
  • Pregnancy*
  • Primary Ovarian Insufficiency / chemically induced*
  • Uterine Neoplasms / drug therapy*
  • Uterine Neoplasms / pathology

Substances

  • Dactinomycin
  • Etoposide
  • Cisplatin
  • Methotrexate

Supplementary concepts

  • PEA-M regimen