Abstract
A case is reported of a metastatic gestational choriocarcinoma in a 25-year old woman. Extensive pelvic, pulmonary and brain metastases were associated with clinically manifest thyrotoxicosis. Multiagent chemotherapy alone was successful in achieving a durable remission and euthyroid state. The chemotherapy regimen consisted of cis-platinum, etoposide, actinomycin-D, and intrathecal methotrexate (PEA-M). The Patient conceived 2 years after completing therapy and gave birth at term to a normal infant.
MeSH terms
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Adult
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Antineoplastic Combined Chemotherapy Protocols / adverse effects*
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Brain Neoplasms / drug therapy*
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Brain Neoplasms / secondary*
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Choriocarcinoma / drug therapy*
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Choriocarcinoma / secondary*
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Cisplatin / administration & dosage
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Dactinomycin / administration & dosage
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Etoposide / administration & dosage
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Female
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Humans
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Lung Neoplasms / drug therapy
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Lung Neoplasms / secondary
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Methotrexate / administration & dosage
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Pregnancy Complications, Neoplastic / drug therapy*
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Pregnancy*
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Primary Ovarian Insufficiency / chemically induced*
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Uterine Neoplasms / drug therapy*
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Uterine Neoplasms / pathology
Substances
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Dactinomycin
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Etoposide
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Cisplatin
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Methotrexate