HLA-DR expression on M cells overlying Peyer's patches is a common feature of human small intestine

Acta Pathol Jpn. 1991 Nov;41(11):818-23. doi: 10.1111/j.1440-1827.1991.tb01624.x.


The expression of major histocompatibility complex (MHC) class II (HLA-DR) antigens on M cells within follicle-associated epithelial cells (FAE) covering Peyer's patches was analyzed immunohistochemically. HLA-DR antigens were strongly expressed on M cells and cells with dendritic morphology, whereas other FAE covering Peyer's patches showed weak, but definite staining. Dendritic cells were also positive for S-100 protein and IL-1. These findings suggest that M cells as well as dendritic cells within FAE form an antigen-presenting cell system and contribute to the first information releaser for the mucosal immune system.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Dendritic Cells / cytology
  • Dendritic Cells / immunology
  • Dendritic Cells / ultrastructure
  • Epithelial Cells
  • Epithelium / immunology
  • Epithelium / ultrastructure
  • HLA-DR Antigens / analysis*
  • Humans
  • Immunohistochemistry
  • Interleukin-1 / analysis
  • Intestinal Mucosa / cytology
  • Intestinal Mucosa / immunology
  • Intestinal Mucosa / ultrastructure
  • Intestine, Small / cytology*
  • Intestine, Small / immunology
  • Intestine, Small / ultrastructure
  • Microscopy, Electron
  • Peyer's Patches / cytology*
  • Peyer's Patches / immunology*
  • Peyer's Patches / ultrastructure
  • S100 Proteins / analysis


  • HLA-DR Antigens
  • Interleukin-1
  • S100 Proteins