Calcium signalling and cell-fate choice in B cells

Nat Rev Immunol. 2007 Oct;7(10):778-89. doi: 10.1038/nri2172.


Alterations in the cytosolic concentration of calcium ions (Ca2+) transmit information that is crucial for the development and function of B cells. Cytosolic Ca2+ concentration is determined by a balance of active transport and gradient-driven Ca2+ fluxes, both of which are subject to the influence of multiple receptors and environmental sensing pathways. Recent advances in genomics have allowed for the compilation of an increasingly comprehensive list of Ca2+ transporters and channels expressed by B cells. The increasing understanding of the function and regulation of these proteins has begun to shift the frontier of Ca2+ physiology in B cells from molecular analysis to determining how diverse inputs to cytosolic Ca2+ concentration are integrated in specific immunological contexts.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • B-Lymphocytes / metabolism*
  • Calcium / metabolism
  • Calcium Signaling / physiology*
  • Cytosol / metabolism
  • Humans
  • Inositol 1,4,5-Trisphosphate / metabolism
  • Phospholipase C gamma / metabolism
  • Receptors, Antigen, B-Cell / physiology


  • Receptors, Antigen, B-Cell
  • Inositol 1,4,5-Trisphosphate
  • Phospholipase C gamma
  • Calcium